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Welcome to C.I.T.!

Welcome to C.I.T., the Centre for Tissue Engineering of the University of Pavia!

C.I.T. was founded as interdepartmental and interdisciplinary research centre in 2006, joining competences and research interests from some departments of the University of Pavia (Depts. of Biochemistry, Biology, Experimental Medicine, Farmaceutics, Orthopaedics, Pediatrics, Physical Chemistry, Systems and Computer Science).

Our missions are:
  • The collaboration between research subjects, public or private, academic or commercial, national or international
  • The formation of young researchers
  • The organization of didactical activities for undergraduated and graduated students
  • The promotion of seminars and congresses dedicated to Tissue Engineering
  • The development of products and services for the national health system

 

Our researches are in the field of:

  • Tissue Engineering, especially related to bony and muscular tissues
  • Analysis of the immunological and biochemical properties of bacterial adhesins for components of the extracellular matrix proteins
  • Interaction of different type of biomaterials with eukaryotic cells such as human osteoblasts, fibroblasts, platelets and macrophages (biocompatibility and citotoxicity studies)
  • Tissue engineering studies using stem cells and different type of scaffolds
  • Studies on bacterial infection (caused by S.aureus, S.epidermidis and E.coli strains) to biomaterials and strategies to avoid such infections
  • Bioinformatics for Tissue Engineering
  • Translational Bioinformatics
    • Data warehouse approaches for intelligent exploration of phenotypic data
    • Automated and integrated search on biological data and knowledge repositories
    • Text mining of scientific literature
    • Reasoning and decision support systems, that is, the definition of a workflow management environment following an epistemological model of scientific reasoning, in order to allow researchers to structure and organize each step of scientific discovery and results demonstration
  • Genetic Dissection of Complex Traits
    • Development of new analytical methods for genomic data analysis using machine learning- and information theory-based approaches
  • Genomics
    • Temporal clustering of gene expression time series using temporal abstraction-based clustering of gene expression profiles and Bayesian clustering of gene expression profiles
    • Gene network reconstruction using methods based on Bayesian networks and precedence temporal networks
  • Proteomics
    • New strategy for the analysis of SELDI/MALDI-TOF serum data to develop diagnostic methods based on proteomic profiles of body fluids generated by mass spectrometry
  • Identification of morphological and molecular markers that define the mammalian oocyte’s developmental competence
  • Analysis of the pathways of gene expression in oocytes during folliculogenesis, also following the alteration of the expression of genes involved in the acquisition of the oocyte’s developmental competence
  • Analysis of the meiotic silencing of unsynapsed chromatin during male meiosis in mice carriers of chromosomal structural heterozygosities
  • Study of the molecular mechanisms that alter the differentation of embryonic stem cells into cardiomiocytes cultered in the presence of xenobiotics (e.g., dioxin) 
  • Pluripotent stem cells (e.g., embryonic stem cells or induced pluripotent stem cells, iPS) as in vitro models for the study of thrombopoiesis and inherited thrombocytopenias
  • Biological effets of radiations on pluripotent stem cells
  • Scaffolds for tissue regeneration
    • Physico-chemical and biological evaluation of new biopolymers for bone regeneration
    • Development of scaffolds for bone regeneration made of a new biopolymer
    • Development of scaffolds for stem cell delivery
    • Study of new scalable preparation methods for 2D and 3D polymeric scaffolds
    • Preparation and characterization of drug-hydroxyapatite nanocomposites for target delivery to bones
    • Investigations on the influence of gamma irradiation on (biodegradable) polymeric scaffolds in in vitro/in vivo performances
  • Drug delivery systems for biotech drugs
    • Development of a one shot vaccine formulation based on polymeric nanoparticles
    • Development of a microparticulate bioadhesive buccal formulation for the target delivery of anti-caries drugs to teeth
 

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