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Our Research Activities PDF Print E-mail

Our researches are in the field of:

  • Tissue Engineering, especially related to bony and muscular tissues
  • Analysis of the immunological and biochemical properties of bacterial adhesins for components of the extracellular matrix proteins
  • Interaction of different type of biomaterials with eukaryotic cells such as human osteoblasts, fibroblasts, platelets and macrophages (biocompatibility and citotoxicity studies)
  • Tissue engineering studies using stem cells and different type of scaffolds
  • Studies on bacterial infection (caused by S.aureus, S.epidermidis and E.coli strains) to biomaterials and strategies to avoid such infections
  • Bioinformatics for Tissue Engineering
  • Translational Bioinformatics
    • Data warehouse approaches for intelligent exploration of phenotypic data
    • Automated and integrated search on biological data and knowledge repositories
    • Text mining of scientific literature
    • Reasoning and decision support systems, that is, the definition of a workflow management environment following an epistemological model of scientific reasoning, in order to allow researchers to structure and organize each step of scientific discovery and results demonstration
  • Genetic Dissection of Complex Traits
    • Development of new analytical methods for genomic data analysis using machine learning- and information theory-based approaches
  • Genomics
    • Temporal clustering of gene expression time series using temporal abstraction-based clustering of gene expression profiles and Bayesian clustering of gene expression profiles
    • Gene network reconstruction using methods based on Bayesian networks and precedence temporal networks
  • Proteomics
    • New strategy for the analysis of SELDI/MALDI-TOF serum data to develop diagnostic methods based on proteomic profiles of body fluids generated by mass spectrometry
  • Identification of morphological and molecular markers that define the mammalian oocyte’s developmental competence
  • Analysis of the pathways of gene expression in oocytes during folliculogenesis, also following the alteration of the expression of genes involved in the acquisition of the oocyte’s developmental competence
  • Analysis of the meiotic silencing of unsynapsed chromatin during male meiosis in mice carriers of chromosomal structural heterozygosities
  • Study of the molecular mechanisms that alter the differentation of embryonic stem cells into cardiomiocytes cultered in the presence of xenobiotics (e.g., dioxin) 
  • Pluripotent stem cells (e.g., embryonic stem cells or induced pluripotent stem cells, iPS) as in vitro models for the study of thrombopoiesis and inherited thrombocytopenias
  • Biological effets of radiations on pluripotent stem cells
  • Scaffolds for tissue regeneration
    • Physico-chemical and biological evaluation of new biopolymers for bone regeneration
    • Development of scaffolds for bone regeneration made of a new biopolymer
    • Development of scaffolds for stem cell delivery
    • Study of new scalable preparation methods for 2D and 3D polymeric scaffolds
    • Preparation and characterization of drug-hydroxyapatite nanocomposites for target delivery to bones
    • Investigations on the influence of gamma irradiation on (biodegradable) polymeric scaffolds in in vitro/in vivo performances
  • Drug delivery systems for biotech drugs
    • Development of a one shot vaccine formulation based on polymeric nanoparticles
    • Development of a microparticulate bioadhesive buccal formulation for the target delivery of anti-caries drugs to teeth